Release of bioactive compounds by biomimetic polymer coatings
Biomimetic polymer coatings can be used as reservoirs for the release of bioactive compounds from the surface of implants. A “Layer-by-Layer” coating manufactured from biocompatible polyelectrolytes will be used. It has been shown that a cyclodextrin derivative, viewed as a vector for drugs, could be efficiently incorporated by diffusion within the coating. The next step, and goal of my traineeship, will be to characterize and study the incorporation of complexes formed between the vector and various drugs (called “inclusion complexes”), as well as the following delivery of the drugs to cells cultured on top of the coatings.