Morphogenesis of vascular networks in living systems Two examples :

the chicken-embryo yolk sac and the jellyfish Aurelia aurita

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- Annemiek J.M. Cornelissen
Laboratoire Matière et Systèmes Complexes
CNRS & Université Paris Diderot

- Abstract
Morphogenesis of living systems is controlled by a complex of processes in which also mechanical forces play a role. Mechanical forces can contribute either on a cellular scale by impacting on the signaling pathways, or on a tissue scale affecting the cell movements and deformations (compression, extension, intercalation, and rearrangement etc). In my research I aim to understand how mechanical self-organized processes are involved in the morphogenesis of vascular network structures. I will present two animal models, the jellyfish Aurelia aurita and the chicken embryo yolk-sac in which we challenge the hypothesis that tissue growth induces mechanical constraints that are implicated in governing the pattern of their vascular network.

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- References

  • A R Pries, A J M Cornelissen, A A Sloot, M Hinkeldey, M R Dreher, M Höpfner, M W Dewhirst & T W Secomb
    Structural adaptation and heterogeneity of normal and tumor microvascular networks.
    PLoS Computational Biology, 5 (5), e1000394, 2009 Online
  • Gambini C, Abou B, Ponton A, Cornelissen AJ
    Micro- and macrorheology of jellyfish extracellular matrix.
    Biophysical Journal, 102 (1), 1-9, 2012 Online

13/01/2014

IBIOM 2007 - Crédits - MàJ : 23/01/2014  -  RSS spip

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